Accelerating Therapeutic DiscoveryTM

News From The Alpha-1 Project

Entries for December 2018

Based on the most recent data from the ADVANCE clinical trial, the Company is reviewing the learnings from the study, notably on the AAVrh.10 capsid in order to inform further development of gene therapy candidates for the treatment of rare diseases. The Company plans to conduct additional preclinical studies to determine the best gene therapy candidate to advance. The Company plans to provide an update on the rare disease programs in the first half of 2019 and will not submit an IND application for ADVM-053 for the treatment of hereditary angioedema (HAE) in the fourth quarter of 2018.

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London, UK and Redwood City, California, USA, 5 December 2018 – Mereo BioPharma Group plc (AIM: MPH) (“Mereo”, the “Company” or the “Group”), the clinical stage UK based biopharmaceutical company focused on rare diseases, and OncoMed Pharmaceuticals, Inc. (NASDAQ: OMED) (“OncoMed”), a NASDAQ listed oncology-focused clinical stage biopharmaceutical business, today announce the proposed combination of Mereo and OncoMed (the “Transaction”). The Transaction has been unanimously approved by the Board of Directors of each company.

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