Accelerating Therapeutic DiscoveryTM

News From The Alpha-1 Project

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MIAMI, FL and GAINESVILLE, FL (March 26, 2013) - The Alpha-1 Project (TAP) today announced its first investment in a potential new treatment for Alpha-1 Antitrypsin Deficiency (Alpha-1), the most common known genetic risk factor for emphysema. TAP is partially funding further trials of a gene therapy treatment being developed by Applied Genetic Technologies Corporation (AGTC).

Alpha-1 is a genetic disorder characterized by low levels of or absent alpha-1 antitrypsin protein in the blood. Alpha-1 patients are at risk for severe lung disease as adults and liver disease at any age. Up to 3% of all people diagnosed with COPD may have undetected Alpha-1. The condition can lead to severe disability and reduced life expectancy.

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MIAMI -- Jean-Marc D. Quach, a longtime leader in healthcare management and marketing, has been named executive director of The Alpha-1 Project, a subsidiary of the Alpha-1 Foundation.

Quach, of Englewood Cliffs, NJ, is not a newcomer to the world of Alpha-1 Antitrypsin Deficiency. From 1999-2004, he was vice president and general manager of Express Scripts Specialty Distribution Services, where he worked with AlphaNet and Bayer to create a "direct distribution" model for Prolastin®, then the only Alpha-1 augmentation treatment available. The business model is still used for orphan and other high-risk or shortage-prone drug products.

“Jean-Marc, with his record of leadership and innovation, is the perfect match for the Foundation’s initiative to speed the development of new therapies for Alpha-1,” said John W. Walsh, Foundation president and CEO.

The Alpha-1 Project (TAP) is a for-profit, wholly owned subsidiary of the not-for-profit Alpha-1 Foundation. “TAP is a venture philanthropy company,” said Marcia F. Ritchie, vice president and chief operating officer of both TAP and the Alpha-1 Foundation. “The goal is to accelerate the discovery, development and commercialization of treatments and drug therapies for those with Alpha-1,” Ritchie said.

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